Harnessing the Potential of Vesicular Stomatitis Virus as a Novel Therapeutic Strategy for Cancer Treatment
نویسندگان
چکیده
Harnessing the Potential of Vesicular Stomatitis Virus as a Novel Therapeutic Strategy for Cancer Treatment
منابع مشابه
Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer
In the last decade, we have gained significant understanding of the mechanism by which vesicular stomatitis virus (VSV) specifically kills cancer cells. Dysregulation of translation and defective innate immunity are both thought to contribute to VSV oncolysis. Safety and efficacy are important objectives to consider in evaluating VSV as a therapy for malignant disease. Ongoing efforts may enab...
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Vesicular stomatitis virus (VSV) forms pseudotypes with envelope components of reticuloendotheliosis virus (REV). The VSV pseudotype possesses the limited host range and antigenic properties of REV. Approximately 70% of the VSV, Indiana serotype, and 45% of VSV, New Jersey serotype, produced from the REV strain T-transformed chicken bone marrow cells contain mixed envelope components of both VS...
متن کاملSyncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer.
Vesicular stomatitis virus (VSV) selectively replicates in tumor but not in normal cells and is being developed as an oncolytic agent for cancer therapy. Here we report the construction of a recombinant VSV capable of inducing syncytia formation between tumor cells through membrane fusion at neutral pH, which led to enhanced oncolytic properties against multifocal hepatocellular carcinoma (HCC)...
متن کاملVesicular Stomatitis Virus
Defective particles were the major product after undiluted passage of certain temperature-sensitive (ts) mutants of the Indiana C strain of vesicular stomatitis virus in BHK-21 cells at the permissive temperature (31 C). Essentially homogeneous preparations of defective particles were obtained with the wild-type and individual ts mutants. The defective particles associated with some of the ts m...
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ژورنال
عنوان ژورنال: Iranian Journal of Blood and Cancer
سال: 2023
ISSN: ['2008-4595', '2008-4609']
DOI: https://doi.org/10.58209/ijbc.15.2.117